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KMID : 0615720160330030001
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Jouranl of Korean Acupuncture and Moxibustion society
2016 Volume.33 No. 3 p.1 ~ p.16
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Effect of Gentianae Macrophyllae Radix Pharmacopuncture at Hwando (GB30) on Neuropathic Pain in Tibial and Sural Nerve Transected Rats
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Lee Ook-Jae
Kim Seon-Wook
Shin Jeong-Cheol
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Abstract
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Objectives: The objective of this study was to investigate the effects of Gentianae Macrophyllae Radix pharmacopuncture (GP) at Hwando (GB30) in neuropathic pain induced rats.
Methods: Neuropathic pain in rats was induced by tibial and sural nerve transection. The rat subjects were divided into 6 groups : normal (Nor, n ＝ 5), control (Con, n ＝ 5), neuropathic pain- induced injected at GB30 with 1 ㎎/㎏ GP (GP-A, n ＝ 5), 5 ㎎/㎏ GP (GP-B, n ＝ 5) and 20 ㎎/㎏ GP (GP-C, n ＝ 5), and neuropathic pain-induced injected with 1㎎/㎏ Tramadol (Tramadol, n＝5). Injections were administered 2 times a week for a total of 5 treatments. After each treatment plantar withdrawal response was measured and after all 5 treatments were completed c-fos, Bax, Bcl-2, mGlu5 and leukocytes in the blood were analyzed.
Results: 1. Groups GP-A, GP-B and GP-C showed a meaningful decrease in the withdrawal response of mechanical allodynia compared to the control group.
2. Groups GP-A, GP-B and GP-C showed a meaningful decrease in the expression of c-fos compared to the control group.
3. Groups GP-A and GP-C showed a meaningful increase in the expression of mGluR5 compared to the control group.
4. Groups GP-A, GP-B and GP-C showed a meaningful decrease in Bax/Bcl-2 ratio compared to the control group.
Conclusions: These results suggest that Gentianae Macrophyllae Radix pharmacopuncture at Hwando (GB30) could decrease mechanical allodynia and could have analgesic and neuroprotective effects on the model of neuropathic pain.
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KEYWORD
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Neuropathic pain, Gentianae Macrophyllae Radix, Pharmacopuncture, Hwando (GB30)
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